French AIDS campaign launched at long last

H3K27 Demethylases, at Long Last

Methylation of lysine 27 on histone H3 (H3K27me) by the Polycomb complex (PRC2) proteins is associated with gene silencing in many developmental processes. A cluster of recent papers (Agger et al., 2007; De Santa et al., 2007; Lan et al., 2007; Lee et al., 2007) identify the JmjC-domain proteins UTX and JMJD3 as H3K27-specific demethylases that remove this methyl mark, enabling the activation o...

The Last Rites of Public Campaign Financing?

1 billion campaign officially launched for Stanford Hospital and School of Medicine

Stanford University President John Hennessy yesterday announced the launch of a campaign to transform health care at a local, national and global level. The $1 billion Campaign for Stanford Medicine will make investments in medical research and teaching, build a new Stanford hospital, and accelerate the translation of new medical knowledge into leading-edge coordinated patient care. The medical...

The end of a long search: at last thrombopoietin.

At most at last

Recent pragmatic accounts derive the ignorance inferences to which superlative modifiers give rise as quantity implicatures in a neo-Gricean framework. While these approaches successfully account for the interaction of at least with modals, the behavior of at most remains a puzzle. I propose that at most is composed of an antonymizing operator and at least and show how this accounts for the int...